Programme Eurotau Oct. 25

Preliminary programme – some changes may occur

Welcome address:

8:30-9:00 – Luc Buée and RCF representative

9:00-11:00 Session 1 (Chairs: A. Rovelet-Lecrux & J. Attems)

  • 9:00 – Johannes Attems (UK) Tau in ageing/ AD/ PART and frontotemporal lobar degeneration
  • 9:15 – Anne Rovelet-Lecrux (France) Clinical and neuropathological diversity of tauopathy in MAPT duplication carriers
  • 9:30 – Ruiqing Ni (Switzerland) High-resolution non-invasive whole brain optoacoustic tomography imaging of tau in P301L tauopathy mice
  • 9:40 – Tiago Gil Oliveira (Portugal) Primary age-related tauopathy (PART) and Alzheimer’s disease show differential magnetic resonance imaging atrophy patterns
  • 9:50 – Eugeen Vanmechelen (Belgium) Two plasma p-tau SIMOA-based assays using a shared synthetic calibrator peptide for detection of AD pathology
  • 10:00 – Roberto Simone (UK) Natural antisense transcripts containing an embedded mammalian-wide interspersed repeat repress MAPT translation and aid proteostasis in neurodegeneration
  • 10:15 – Karine Cambon (France) Neuronal Tau pathology transfers to astrocytes and induces their loss according to Tau aggregation state in mouse models
  • 10:25 – Kevin Richetin (Switzerland) Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer’s disease
  • 10:35 – Michael Heneka (Germany-Luxembourg) How microglia modulate tau pathology
  • 10:50 – Questions

11:00-11:30 Coffee break

11:30-13:00 Rainwater Prize ceremony

  • 11:30 – Introduction                   
  • 11:35 – Richard Carmona – Prize overview
  • 11:50 – Philippe Amouyel (Chairperson: L Buée) – JPND & European funding for NDD
  • 12:15 – Celeste Karch, Rainwater Prize for Innovative Early Career Scientist  (Chair: Leonard Petrucelli)                              
  • 12:30 – David Holtzman, Rainwater Prize forOutstanding Innovation in Neurodegenerative Disease Research  (Chairperson: Howard Feldman)                   
  • 12:45 – Todd and Matt Rainwater thank winners, nominators, scientists
  • 12:55 – Amy Rommel – About prize & nominations open
  • 12:59 – Luc Buee closes the Rainwater Ceremony

13:00-14:30 Lunch & Poster exhibition

14:30-16:00 Session 2 (Chairs: A. Rommel & L. Buée)

  • 14:30 – David Holtzman, 2020 Rainwater Prize forOutstanding Innovation in Neurodegenerative Disease Research (USA)
  • 14:50 – Michel Goedert, 2019 Rainwater Prize forOutstanding Innovation in Neurodegenerative Disease Research (UK) Cryo-EM structures of amyloid filaments from human brain
  • 15:10 – Celeste Karch, 2020 Rainwater Prize for Innovative Early Career Scientist (USA) Molecular and cellular drivers of tauopathy
  • 15:30 – Mathieu Bourdenx (France) Chaperone-mediated autophagy: a gatekeeper of neuronal proteostasis
  • 15:40 – Wiep Scheper (The Netherlands) Cell type-specific proteostatic responses to tau pathology
  • 15:50 – Lukasz A Joachimiak (USA) DnaJC7 binds natively forlded structural elements in tau to inhibit amyloid formation

16:00-16:30 Coffee break

16:30-18:00 Session 3 (Chairs: I. Landrieu & Y. Fichou)

  • 16:30 – Illana Gozes (Israel) Novel insights to ADNP/NA/Tau protein interactions dictating brain development and aging
  • 16:40 – Eliana Nachman (Belgium) Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species
  • 16:50 – Romain La Rocca (France) Three zinc binding sites of Tau and their role in tau aggregation
  • 17:00 – Cláudio M. Gomes (Portugal) Dynamic interactions and Ca2+-binding modulate the chaperone activity of S100B preventing tau aggregation and seeding
  • 17:10 – Davide Tampellini (France) Enhancement of synaptic stimulation induces tau clearance via the autophagosomal/lysosomal pathway
  • 17:20 – Marina Rierola (Germany) Tau shapes microtubule-dependent transport in the dendrites 
  • 17:30 – Laura Vallés Saiz (Spain) Tau expression in the kidney: cell distribution and physiological function
  • 17:40 – Marie Galas (France) Revisiting the link between tau and the neuronal cell cycle in Alzheimer’s disease: an unexpected role for nuclear tau
  • 17:50 – Mahmoud Maina (UK / USA) The involvement of Tau in nucleolar function and stress response

18:00-20:00 Rainwater Prize reception (OPEN to all Eurotau participants)