Preliminary programme: some changes may occur
8:15 Opening
8:25-8:30 – Luc Buée – Welcome address
8:30-8:45 Luc Buée & Marion Levy (Vaincre Alzheimer) Associations – opportunities for funding
8:45-9:00 – Flash talks
- Neha Basheer (Slovak rep.) Poster 31
- Kevin L Batenburg (NL) Posters 15-16
- Amandine Grimm (CH) Poster 19
9:00-11:00 Session 1 Tau & neuropathology (W Scheper & P Maquet)
- 9:00 – Pierre Maquet (B) Early brainstem tau relates to cortical excitability in healthy aging
- 9:15 – Bernard Hanseeuw (B) Specific post-translational modifications of the soluble tau protein distinguish between Alzheimer’s disease, 4R-, and 3R-tauopathies
- 9:30 – Tiago Gil Oliveira (P) Lewy body co-pathology contributes to frontal lobe atrophy in Alzheimer’s disease and primary age-related tauopathy (PART)
- 9:40 – Camila De Ávila (USA) Phosphorylated tau is present in the human nucleus incertus of the brain
- 9:50 – Wiep Scheper (NL) – Understanding Granulovacuolar Degeneration Bodies: A neuron-specific response to tau pathology
- 10:05 – Naruhiko Sahara (J) Dissecting mechanisms of tauopathy using in vivo multimodal imaging techniques on tauopathy mouse models
- 10:15 – Len Petrucelli (USA) TMEM106b in FTLD-TDP & PSP
- 10:30 Questions
10:45-11:00 Flash talks
- Mohammadreza Allahyartorkaman (Taïwan) Poster 55
- Clément Danis (F) Posters 69, 73 & 74
- Barbara Sarkany (NL) Poster 65
11:00-11:30 Coffee break
11:30-12:30 Rainwater Prize ceremony (Chair: A. Rommel & L. Buée)
- 11:30 – Richard Carmona – Welcome & Prize history
- 11:35 – Jeremy Smith – Partnership Rainwater Prize / Eurotau
- 11:45 – Maria Carillo
- 11:50 – Frank Bennett (Ionis), Don Cleveland (UCSD) Tim Miller (WU St Louis), Rainwater Prize for Outstanding Innovation in Neurodegenerative Disease Research
- 12:05 – Luc Buée
- 12:10 – Susanne Wegmann, Rainwater Prize for Innovative Early Career Scientist
- 12:15 – Jordan Brainerd – Closing and Adjournment for Lunch
12:30-14:00 Lunch & Poster exhibition
14:00-16:00 Session 2 (Chairs: Howard, Eckhard, Len, Irene)
- 14:00 Amy Rommel – Overview RCF
- 14:05 Howard Feldman
- 14:15 Michel Goedert – Cryo-EM structures of amyloid filaments from human brains
- 14:35 Eckard Mandelkow
- 14:40 Susanne Wegmann – Tau aggregation and liquid droplets
- 15:00 Len Petrucelli
- 15:05 Triple presentation:
- Frank Bennett continues to advance antisense technology and expand Ionis’s drug discovery platform. He has been working on antisense oligonucleotides for the past 30 years. He started investigating the potential of antisense technology for developing therapies for ALS and spinal muscular atrophy (SMA) almost 20 years ago.
- Don Cleveland discovered, purified, and determined the properties of the tau protein. With Bennett and Miller, he developed designer DNA drugs that utilize technology that silence genes in the human nervous system that have been studied in seven different clinical trials, aiming to treat ALS, Huntington’s, Parkinson’s, and AD.
- Tim Miller has been a leader for over two decades in helping uncover effective therapies for neurodegenerative diseases including ALS and tauopathies. The latest results using the SOD1 ASO developed with Cleveland and Bennett show a dramatic effect on slowing of SOD1 ALS. His lab led the early stages of development of BIIB080/IONIS-MAPTRx, an antisense drug that lowers tau mRNA and protein as a therapy for tauopathies.to tau
- 15:45 Panel discussion (moderator: Irene Litvan)
16:00-16:30 Coffee break
16:30-18:15 Session 3 (K Bowles & MB Maina)
- 16:30 – Maria Grazia Spillantini (UK) Glial cells in P301S tau transgenic mice show ageing-related features
- 16:45 – Goonho Park (USA) Tauopathy-associated PERK variants impair signal transduction and promote tau aggregation
- 16:55 – Amantha Thathiah (USA) Live-cell visualization of tau aggregation in human neurons
- 17:05 – Kathryn Bowles (UK) MAPT S305 mutations alter neuron and astrocyte function
- 17:15 – Ana Melo de Farias (F), Alzheimer’s risk gene PTK2B affects TAU phosphorylation in human induced neurons
- 17:25 – Mahmoud B Maina (UK) Frontotemporal dementia-associated tau mutations induce altered nucleolar structure before cell death
- 17:35 – Roman Praschberger (B) Neuronal identity defines a-synuclein and tau toxicity
- 17:45 – Martha Foiani (UK) Proteomic signature of vulnerable neurons in Alzheimer’s disease brains
- 17:55 – Patrícia A. Gomes (P) Isolation of spontaneously-released brain extracellular vesicles: implications for brain pathology
- 18:05 – Questions
18:30-20:30 Rainwater Prize reception (OPEN to all Eurotau participants)
