Programme Eurotau Oct. 26

Preliminary programme – some changes may occur

8:30-9:00 – Plenary lecture

Kenneth Kosik (USA) A Rite of Passage: Tau’s Route Between And Within Cells

9:00-11:00 – Session 4 (Chairs: A. Mudher & I. Ferrer)

  • 9:00 – Eckhard Mandelkow (S. Wegmann) (Germany) Recent insights into Tau seeding and phosphorylation
  • 9:15 – Susanne Wegmann (Germany) Condensating the interactions of tau
  • 9:25 – Louise Serpell (UK) The role of the core of tau paired helical filaments in AD and other tauopathies
  • 9:35 – Davide Tampellini (France) Enhancement of synaptic stimulation induces tau clearance via the autophagosomal/lysosomal pathway
  • 9:45 – Amrit Mudher (UK) Tau aggregation and spread of pathology in Drosophila
  • 9:55 – Isidre Ferrer (Spain) Importance of host tau in tau seeding and spreading in tauopathies
  • 10:10 – Diane Hanger (UK) Truncated tau as a model of human tauopathy
  • 10:25 – Marc Dhenain (France) Induction of tau lesions in amyloid-bearing mice and in primates after inoculation of Alzheimer brain extracts
  • 10:35 – Questions

10:50-11:20 Coffee break

11:20-13:00 Session 5 (Chairs: D. Hanger & I. Sotiropoulos)

  • 11:20 – Delphine Boche (UK) Neuroinflammation, peripheral immune cells and tau pathology in FTLD-tau
  • 11:30 – Michael Heneka (Germany-Luxembourg) How microglia modulate tau pathology
  • 11:45 – Karine Cambon (France) Neuronal Tau pathology transfers to astrocytes and induces their loss according to Tau aggregation state in mouse models
  • 11:55 – Kevin Richetin (Switzerland) Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer’s disease
  • 12:05 – Ioannis/John Sotiropoulos (Portugal) A novel method of spontaneously-released extracellular vesicles isolation from mouse and human brain
  • 12:15 – Elodie Leroux (France) Extracellular vesicles and tau seeding among tauopathies
  • 12:25 – Karen Duff (UK) New cell model for FTD tauopathy
  • 12:40 – Questions
  • 12:55 – Flash talks
    • AC Sandhof (Germany) A new C. elegans model for intercellular tau spreading discovers novel modifyers of tau propagation
    • Lauren VC Miller (UK) Tau seeded aggregation occurs in a non-linear manner in organotypic slice cultures and…
    • Neil S Donison (Canada) The role of LRRK2 in the phosphorylation of Tau (Thr175) associated with TBI

13:15-14:30 Lunch & Poster exhibition

14:30-16:00 Session 6 (Chairs: S. Wegmann & M. Dhenain)

  • 14:30 – Eliana Nachman (Belgium) Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species
  • 14:40 – Evgeni Ponimaskin (Germany) Amelioration of Tau pathology and memory deficits by targeting serotonin receptors
  • 14:50 – Maria-Elena Avale (Argentina) Regulation of tau mis-splicing prevents cognitive and motor deficits in a preclinical model of tauopathy
  • 15:00 – Isabelle Landrieu (France) Single domain antibody fragments: new tools for studying Tau as a target for therapy
  • 15:10 – Dirk Beher (Switzerland) OGA inhibitors as multimodal drug candidates for tau- and alpha-synucleinopathies
  • 15:20 – Norbert Zilka (Slovakia) Tau vaccine AADvac1 trains immune system to produce therapeutic antibodies against disease tau species in Phase II clinical trial
  • 15:30 – Philippe Verwaerde (France) EZEPROGIND a new progranulin modulator for the treatment of PSP
  • 15:40 -Questions

16:00-16:30 Coffee break

16:30-17:40 Session 7 (Chairs: C. Croft & E. Planel)

  • 16:30 – Marco Luppi (Italy) Deep hypothermia stimulates a neuroprotective process reversing the accumulation of hyperphosphorylated tau protein in the rat hippocampus
  • 16:40 – Emmanuel Planel (Canada) Circadian rhythms of tau phosphorylation and secretion are in antiphase and driven by body temperature
  • 16:50 Marie-Ange De Fisenne (Belgium) Alzheimer PHF-tau do not spread tau pathology to the brain via the retinotectal pathway after intraocular injection in mouse models
  • 17:00 – Cara Croft (UK) Understanding mechanisms to target aggregated tau turnover
  • 17:10 – Dillon Rinauro (UK) Validating metainference cryo-EM predictions of site-specific posttranslational modifications on tau-microtubule complex stability
  • 17:20 Questions

17:30 Poster prize and farewell